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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1MCIX6
Molecular formula	C19H15ClN6O3S2
IUPAC name	1-(3-chlorophenyl)-3-[[5-methyl-4-[2-(2-methyl-1,3-thiazol-4-yl)-1,3-thiazol-4-yl]-1,2-oxazole-3-carbonyl]amino]urea
Molecular weight	474.938
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	3.7
Synonyms	MLS000834943 SMR000461459 CCG-53089 HMS2795H12 MolPort-002-925-027 1-(3-chlorophenyl)-3-[[5-methyl-4-[2-(2-methyl-1,3-thiazol-4-yl)-1,3-thiazol-4-yl]-1,2-oxazole-3-carbonyl]amino]urea SR-01000642278-1 MCULE-3985898782 N'-(3-chlorophenylcarbamoyl)-5-methyl-4-[2-(2-methyl-4-thiazolyl)-4-thiazolyl]isoxazole-3-carbohydrazide ZINC3119959 CHEMBL1524716 [ Show all ]
Inchi Key	BPEAWAGQVZSVPR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15ClN6O3S2/c1-9-15(13-7-31-18(23-13)14-8-30-10(2)21-14)16(26-29-9)17(27)24-25-19(28)22-12-5-3-4-11(20)6-12/h3-8H,1-2H3,(H,24,27)(H2,22,25,28)
PubChem CID	2744894
ChEMBL	CHEMBL1524716
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6228.0 nM	PubChem BioAssay data set	ChEMBL

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