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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuromedin-K receptor
Species	Rattus norvegicus (Rat)
Gene	Tacr3
Synonym	Tac3r SP-N receptor Nmkr NKR NK3 receptor NK-3R NK-3 receptor neuromedin K receptor neurokinin beta receptor Neurokinin B receptor Tachykinin receptor 3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	452
Amino acid sequence	MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
UniProt	P16177
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3154
IUPHAR	362
DrugBank	N/A

Ligand

Name	CHEMBL449347
Molecular formula	C28H31NO2
IUPAC name	(2R,3R)-2-benzhydryl-3-[(2-methoxyphenyl)methoxy]-1-azabicyclo[2.2.2]octane
Molecular weight	413.561
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50280460 (2R,3R)-2-(2,2-Diphenyl-ethyl)-3-(2-methoxy-benzyloxy)-1-aza-bicyclo[2.2.2]octane
Inchi Key	QXSIOQKZUFLLLE-VSGBNLITSA-N
Inchi ID	InChI=1S/C28H31NO2/c1-30-25-15-9-8-14-24(25)20-31-28-23-16-18-29(19-17-23)27(28)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-28H,16-20H2,1H3/t27-,28-/m1/s1
PubChem CID	44368326
ChEMBL	CHEMBL449347
IUPHAR	N/A
BindingDB	50280460
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	100000.0 nM	Bioorg. Med. Chem. Lett., (1992) 2:6:559	ChEMBL

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