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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Sus scrofa (Pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	291
Amino acid sequence	AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProt	P79400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Cyanopindolol
Molecular formula	C16H21N3O2
IUPAC name	4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
Molecular weight	287.363
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.0
Synonyms	4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile CHEBI:125406 GTPL132 PDSP2_001078 CTK8E9328 NSC-707473 SCHEMBL353756 (+/-)4-(3-t-butylamino-2-hydroxypropoxy)-1h-indole-2-carbonitrile BRD-A47884604-001-01-7 CYANOPINDOLOL(+/-) PDSP1_001094 69906-85-0 L000210 PDSP2_001585 AC1L4E3D NSC707473 SR-01000597973 (-)-Cyanopindolol 1H-Indole-2-carbonitrile, 4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)- CAS_155346 D0X8ZA PDSP1_001601 81089-45-4 CHEMBL378501 NCI60_038172 RT-012114 (+-)-Cyanopindolol BDBM81499 CYANOPINDOLOL HEMIFUMARATE NSC_155346 SR-01000597973-1 [ Show all ]
Inchi Key	QXIUMMLTJVHILT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3
PubChem CID	155346
ChEMBL	CHEMBL378501
IUPHAR	132
BindingDB	81499
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	263.0 nM	Schlicker et al., PMID1989, Waeber et al., PMID1988	PDSP

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