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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	CHEMBL422471
Molecular formula	C12H18N2
IUPAC name	2-(2,3-dihydroindol-1-yl)-N,N-dimethylethanamine
Molecular weight	190.29
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	2.1
Synonyms	(2-indolinylethyl)dimethylamine AKOS001675959 cid_744368 SMR000122729 2-(2,3-dihydroindol-1-yl)-N,N-dimethylethanamine CBDivE_015848 HMS2370M08 ZINC185131 AB00073802-01 MolPort-001-973-113 [2-(2,3-dihydro-indol-1-yl)-ethyl]-dimethyl-amine, AldrichCPR 1H-Indole-1-ethanamine, 2,3-dihydro-N,N-dimethyl- BAS 02077966 EU-0011905 ST50899066 CHEBI:114471 MCULE-5924756581 [2-(2,3-dihydro-1H-indol-1-yl)ethyl]dimethylamine AC1LEZFB ChemDiv2_000952 SCHEMBL7680979 2-(2,3-dihydro-1H-indol-1-yl)-N,N-dimethylethanamine BDBM50150979 HMS1371L06 STK386817 87482-07-3 MLS000523656 [2-(2,3-Dihydro-indol-1-yl)-ethyl]-dimethyl-amine [ Show all ]
Inchi Key	BNAWSOWKSSIPGW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H18N2/c1-13(2)9-10-14-8-7-11-5-3-4-6-12(11)14/h3-6H,7-10H2,1-2H3
PubChem CID	744368
ChEMBL	CHEMBL422471
IUPHAR	N/A
BindingDB	50150979
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	269.0 nM	PMID6581313	BindingDB
Kd	269.15 nM	PMID6581313	ChEMBL

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