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Name | Kappa-type opioid receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | OPRK1 |
Synonym | K-OR-1 KOR-1 |
Disease | N/A for non-human GPCRs |
Length | 380 |
Amino acid sequence | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV |
UniProt | P41144 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3952 |
IUPHAR | N/A |
DrugBank | N/A |
Name | DIPPA |
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Molecular formula | C22H23Cl2N3OS |
IUPAC name | 2-(3,4-dichlorophenyl)-N-[(1S)-1-(3-isothiocyanatophenyl)-2-pyrrolidin-1-ylethyl]-N-methylacetamide |
Molecular weight | 448.406 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 6.0 |
Synonyms | 2-(3,4-Dichlorophenyl)-N-methyl-N-[(S)-1-(3-isothiocyanatophenyl)-2-pyrrolizinoethyl]acetamide CHEMBL38521 (S)-3,4-Dichloro-N-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)-N-methylbenzeneacetamide LS-182243 2-(3,4-Dichlorophenyl)-N-methyl-N-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide [ Show all ] |
Inchi Key | BNAKCEFXXMHXDQ-OAQYLSRUSA-N |
Inchi ID | InChI=1S/C22H23Cl2N3OS/c1-26(22(28)12-16-7-8-19(23)20(24)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)25-15-29/h4-8,11,13,21H,2-3,9-10,12,14H2,1H3/t21-/m1/s1 |
PubChem CID | 127914 |
ChEMBL | CHEMBL38521 |
IUPHAR | N/A |
BindingDB | 50035471 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Bmax | 3.55 fM mg-1 | PMID7799399 | ChEMBL |
IC50 | 2.2 nM | PMID7799399, PMID8201586 | BindingDB |
IC50 | 2.21 nM | PMID7799399, PMID8201586 | ChEMBL |
Kd | 2.4 nM | PMID7799399 | BindingDB |
Kd | 2.43 nM | PMID7799399 | ChEMBL |
Ke | 0.3 nM | PMID8201586 | ChEMBL |
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