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GPCR

NameThromboxane A2 receptor
SpeciesMus musculus (Mouse)
GeneTbxa2r
SynonymProstanoid TP receptor
TP receptor
TXA2-R
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
UniProtP30987
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795181
IUPHAR346
DrugBankN/A

Ligand

Name10alpha,11alpha-oxido PGA2
Molecular formulaC20H30O5
IUPAC name(Z)-7-[(2R,3R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-6-oxabicyclo[3.1.0]hexan-3-yl]hept-5-enoic acid
Molecular weight350.455
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.9
SynonymsSCHEMBL11568370
(5Z,13E,15S)-10xi,11xi-epoxy-15-hydroxy-9-oxoprosta-5,13-dien-1-oic acid
BDBM82221
QGGPQDSQYUCJOO-MWGDGYRLSA-N
Inchi KeyQGGPQDSQYUCJOO-MWGDGYRLSA-N
Inchi IDInChI=1S/C20H30O5/c1-2-3-6-9-14(21)12-13-16-15(18(24)20-19(16)25-20)10-7-4-5-8-11-17(22)23/h4,7,12-16,19-21H,2-3,5-6,8-11H2,1H3,(H,22,23)/b7-4-,13-12+/t14-,15+,16+,19?,20?/m0/s1
PubChem CID14427890
ChEMBLN/A
IUPHARN/A
BindingDB82221
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID6317122BindingDB

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