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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	3-phenyl-1H-pyrazole-5-carboxylic acid
Molecular formula	C10H8N2O2
IUPAC name	3-phenyl-1H-pyrazole-5-carboxylic acid
Molecular weight	188.186
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.7
Synonyms	ACN-P001108 BAS 09896590 EU-0099922 HMS3356K22 KSC-20-088 1H-Pyrazole-3-carboxylicacid, 5-phenyl- MLS003585704 5-Phenyl-1H-pyrazole-3-carboxylic acid Pyrazole-3-carboxylic acid, 5-phenyl- 5-Phenylpyrazole-3-carboxylic acid SMR000124836 AB1008881 X9056 Z104442688 AKOS000263428 BDBM50241312 CTK0H8940 FT-0678418 J-513035 MCULE-7695606156 3-phenyl-1H-pyrazol-2-ium-5-carboxylate MolPort-000-750-767 5-Phenyl-1H-pyrazole-3-carboxylicacid RP00181 AB0001094 ST2418848 AC1Q1HF3 ACN-001108 ALBB-006580 CCG-202902 EN002251 HMS1648H01 KS-00000YW2 1134-49-2 MLS000067411 3-Phenylpyrazole-5-carboxylic acid P80028 5-phenyl-3-pyrazole carboxylic acid SBB006941 AB08419 STK560194 Y-1625 AJ-72173 BB 0219050 CHEMBL397785 F0348-3292 I14-10741 KUC107418N 1H-Pyrazole-5-carboxylicacid, 3-phenyl- MolPort-000-145-160 5-Phenyl-1H-pyrazole-3-carboxylic acid # Pyrazole-5-carboxylic acid, 3-phenyl- SR-01000597145 AC-26517 ZERO/006131 AKOS000271465 BR-32026 CTK1H3128 FT-0713944 J-517915 MFCD01248821 NCGC00342274-01 5-phenyl-2 h-pyrazole-3-carboxylic acid RP24812 AB00463493-03 ST4123297 AC1Q747X ACN-P001041 ANW-73934 CHEBI:92735 EN300-14809 HMS2206M19 KS-00001NGY 1H-Pyrazole-3-carboxylic acid, 5-phenyl- MLS001065888 4CH-012732 PS-3041 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID SCHEMBL69492 AB1008217 TOS-BB-0266 Y9264 AK-32026 BBL007916 CS-W022423 FS-1871 J-002966 LS-128382 3-(phenyl)-1H-pyrazole-5-carboxylic acid MolPort-000-183-318 5-Phenyl-1H-pyrazole-3-carboxylic acid, AldrichCPR QBPUOAJBMXXBNU-UHFFFAOYSA-N 5071-61-4 SR-01000597145-1 AC1L3RYA ZINC3888534 AKOS005485835 BRN 0609874 DTXSID60150398 GL-0020 KS-00000CEU MFCD05170017 3-Phenyl-1H-pyrazole-5-carboxylic acid, 97% P2021 5-Phenyl-2H-pyrazole-3-carboxylic acid S-3474 AB01334874-02 STK387518 ACN-001041 [ Show all ]
Inchi Key	QBPUOAJBMXXBNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H8N2O2/c13-10(14)9-6-8(11-12-9)7-4-2-1-3-5-7/h1-6H,(H,11,12)(H,13,14)
PubChem CID	121025
ChEMBL	CHEMBL397785
IUPHAR	N/A
BindingDB	50241312
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	101000.0 nM	PMID12930155	BindingDB,ChEMBL

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