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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL3233666
Molecular formula	C26H34ClFN4O2
IUPAC name	1-[5-[4-(2-fluorophenyl)piperazin-1-yl]pentyl]-3,5-dimethyl-5-phenylimidazolidine-2,4-dione;hydrochloride
Molecular weight	489.032
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	None
Synonyms	BDBM50004523
Inchi Key	PRBFQLUJPVQDGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H33FN4O2.ClH/c1-26(21-11-5-3-6-12-21)24(32)28(2)25(33)31(26)16-10-4-9-15-29-17-19-30(20-18-29)23-14-8-7-13-22(23)27;/h3,5-8,11-14H,4,9-10,15-20H2,1-2H3;1H
PubChem CID	90654834
ChEMBL	CHEMBL3233666
IUPHAR	N/A
BindingDB	50004523
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	25520.0 nM	PMID24691057	BindingDB,ChEMBL

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