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GPCR

NameN-arachidonyl glycine receptor
SpeciesHomo sapiens (Human)
GeneGPR18
SynonymGPCRW
G-protein coupled receptor 18
N-arachidonoyol glycine receptor
NAGly receptor
GPR18
DiseaseN/A
Length331
Amino acid sequenceMITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProtQ14330
Protein Data BankN/A
GPCR-HGmod modelQ14330
3D structure modelThis predicted structure model is from GPCR-EXP Q14330.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2384898
IUPHAR89
DrugBankBE0002304

Ligand

NameCHEMBL3221203
Molecular formulaC18H20N2O4S
IUPAC nameethyl 2-[3-[(Z)-(3-oxo-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-2-ylidene)methyl]phenoxy]acetate
Molecular weight360.428
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.2
SynonymsN/A
Inchi KeyPHXLKIQQLZJXSP-PTNGSMBKSA-N
Inchi IDInChI=1S/C18H20N2O4S/c1-2-23-16(21)12-24-14-7-5-6-13(10-14)11-15-17(22)20-8-3-4-9-25-18(20)19-15/h5-7,10-11H,2-4,8-9,12H2,1H3/b15-11-
PubChem CID11187538
ChEMBLCHEMBL3221203
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity19.0 %MedChemComm, (2014) 5:5:632ChEMBL
IC50<10000.0 nMMedChemComm, (2014) 5:5:632ChEMBL
Inhibition22.0 %MedChemComm, (2014) 5:5:632ChEMBL

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