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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL1165734
Molecular formula	C57H76N12O15S2
IUPAC name	(2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
Molecular weight	1233.42
Hydrogen bond acceptor	19
Hydrogen bond donor	16
XlogP	-4.1
Synonyms	BDBM50320456 TAD[CFWKYC]V
Inchi Key	OSAAGHNIQWODAC-MIBPFTBTSA-N
Inchi ID	InChI=1S/C57H76N12O15S2/c1-29(2)47(57(83)84)69-55(81)44-28-86-85-27-43(67-53(79)42(25-45(72)73)63-48(74)30(3)61-56(82)46(59)31(4)70)54(80)65-39(22-32-12-6-5-7-13-32)50(76)66-41(24-34-26-60-37-15-9-8-14-36(34)37)52(78)62-38(16-10-11-21-58)49(75)64-40(51(77)68-44)23-33-17-19-35(71)20-18-33/h5-9,12-15,17-20,26,29-31,38-44,46-47,60,70-71H,10-11,16,21-25,27-28,58-59H2,1-4H3,(H,61,82)(H,62,78)(H,63,74)(H,64,75)(H,65,80)(H,66,76)(H,67,79)(H,68,77)(H,69,81)(H,72,73)(H,83,84)/t30-,31+,38-,39-,40-,41-,42-,43-,44-,46-,47-/m0/s1
PubChem CID	10920324
ChEMBL	CHEMBL1165734
IUPHAR	N/A
BindingDB	50320456
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.11 nM	PMID20043680	BindingDB,ChEMBL

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