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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	C-C chemokine receptor type 7
Species	Homo sapiens (Human)
Gene	CCR7
Synonym	MIP-3 beta receptor Epstein-Barr virus-induced G-protein coupled receptor 1 EBV-induced G-protein coupled receptor 1 EBI1 EBI-1 CDw197 CD197 CCR7 CCR-7 CC-CKR-7 C-C CKR-7 BLR2 [ Show all ]
Disease	N/A
Length	378
Amino acid sequence	MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP
UniProt	P32248
Protein Data Bank	N/A
GPCR-HGmod model	P32248
3D structure model	This predicted structure model is from GPCR-EXP P32248.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4594
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2435858
Molecular formula	C33H39N5O4
IUPAC name	4-[6-methyl-5-[[4-[(5R)-3-(oxan-4-yl)-2-oxo-5-phenylimidazolidin-1-yl]piperidin-1-yl]methyl]pyridin-2-yl]oxybenzamide
Molecular weight	569.706
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.6
Synonyms	4-(6-methyl-5-{4-[(r)-2-oxo-5-phenyl-3-(tetrahydro-pyran-4-yl)-imidazolidin-1-yl]-piperidine-1-ylmethyl}-pyridin-2-yloxy)-benzamide BDBM50441718 OKRZBWWJVVVKHT-PMERELPUSA-N 4-[[6-Methyl-5-[[4-[(5R)-2-oxo-5-phenyl-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-yl]piperidino]methyl]pyridine-2-yl]oxy]benzamide SCHEMBL5573868
Inchi Key	OKRZBWWJVVVKHT-PMERELPUSA-N
Inchi ID	InChI=1S/C33H39N5O4/c1-23-26(9-12-31(35-23)42-29-10-7-25(8-11-29)32(34)39)21-36-17-13-28(14-18-36)38-30(24-5-3-2-4-6-24)22-37(33(38)40)27-15-19-41-20-16-27/h2-12,27-28,30H,13-22H2,1H3,(H2,34,39)/t30-/m0/s1
PubChem CID	58834953
ChEMBL	CHEMBL2435858
IUPHAR	N/A
BindingDB	50441718
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	75.5 %	PMID24090135	ChEMBL

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