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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	2-Methoxyethoxymethyl chloride
Molecular formula	C4H9ClO2
IUPAC name	1-(chloromethoxy)-2-methoxyethane
Molecular weight	124.564
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	0.6
Synonyms	2-methoxy ethoxymethyl chloride 2-Methoxyethoxymethyl chloride, Technical grade 847026-64-6 BDBM85388 CTK3J1136 I14-0060 L001239 methoxy ethoxymethyl chloride RP19610 .beta.-Methoxyethoxymethyl chloride 2-methoxyethoxy chloromethane 2methoxyethoxymethyl chloride AC1Q3VDW BIAAQBNMRITRDV-UHFFFAOYSA- EINECS 223-589-8 Jsp006889 MEM chloride (2-Methoxyethoxymethyl chloride) methoxyethoxymethylchloride (2-methoxy-ethoxy)methyl chloride SCHEMBL329 1-(Chloromethoxy)-2-methoxyethane # 2-methoxyethoxy-methyl chloride 6643-EP2295412A1 Alkoxyethoxymethylchloride chloromethoxyethoxymethane Ethylene Glycol Chloromethyl Methyl Ether KS-000001EV MEM-Cl MolPort-001-768-805 (2-methoxyethoxy)methylchloride TRA0067120 1-Chloromethoxy-2-methoxyethane 2-methoxy-ethoxymethyl chloride 2-methoxyethoxymethylchloride beta-Methoxyethoxymethyl chloride DB-019132 InChI=1/C4H9ClO2/c1-6-2-3-7-4-5/h2-4H2,1H3 M0680 methoxyethoxychloromethane RTR-015853 1-(chloromethoxy)-2-methoxy-ethane 2-Methoxyethoxy methyl Chloride 3970-21-6 ACMC-1AGMY BIAAQBNMRITRDV-UHFFFAOYSA-N Ethane, 1-(chloromethoxy)-2-methoxy- K-8520 MEM chloride, 94% methoxyethyl chloromethyl ether (2-methoxyethoxy)-methyl chloride STR05536 1-Chloro-2,5-dioxahexane 6643-EP2295413A1 ANW-29145 chloromethyl 2-methoxyethyl ether FT-0612838 KSC491C3N MEMCl PubChem10093 (2-methyloxyethyl)oxymethylchlorid ZINC2242622 1-methoxy-2-chloromethoxyethane 2-methoxy-ethoxymethylchloride 2-methoxyethyl chloromethyl ether AC1L2TDS BETA-METHOXYETHOXYMETHYLCHLORIDE DTXSID8063250 J-509862 MEM chloride Methoxyethoxymethyl chloride SC-75748 1-(Chloromethoxy)-2-methoxyethane 2-methoxyethoxy methylchloride 6643-EP1441224A2 AKOS000121064 CAS_3970-21-6 Ethane,1-(chloromethoxy)-2-methoxy- KB-68943 MEM-chloride MFCD00000888 (2-methoxyethoxy)methyl chloride TR-015853 1-Chloromethoxy-2-methoxy-ethane [ Show all ]
Inchi Key	BIAAQBNMRITRDV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H9ClO2/c1-6-2-3-7-4-5/h2-4H2,1H3
PubChem CID	77590
ChEMBL	N/A
IUPHAR	N/A
BindingDB	85388
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1130.0 nM	PMID9933142	BindingDB

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