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Name | Free fatty acid receptor 1 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Ffar1 |
Synonym | FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 |
Disease | N/A for non-human GPCRs |
Length | 300 |
Amino acid sequence | MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK |
UniProt | Q8K3T4 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1795180 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL2022243 |
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Molecular formula | C26H26O3 |
IUPAC name | 2-[5-[[3-(2,6-dimethylphenyl)phenyl]methoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid |
Molecular weight | 386.491 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.9 |
Synonyms | BDBM50382541 SCHEMBL1633689 |
Inchi Key | BHRKGZMWOJNDKC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H26O3/c1-17-5-3-6-18(2)26(17)22-8-4-7-19(13-22)16-29-23-11-12-24-20(14-23)9-10-21(24)15-25(27)28/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,27,28) |
PubChem CID | 23111668 |
ChEMBL | CHEMBL2022243 |
IUPHAR | N/A |
BindingDB | 50382541 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 520.0 nM | PMID24900210, PMID22242551 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417