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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	CHEMBL311159
Molecular formula	C23H23N3O5
IUPAC name	1-[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]-1-methyl-3-[4-(3-nitrophenoxy)phenyl]urea
Molecular weight	421.453
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.7
Synonyms	BDBM50101559 1-(2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-[4-(3-nitro-phenoxy)-phenyl]-urea
Inchi Key	BGRKYPKEPNKVGH-OPAMFIHVSA-N
Inchi ID	InChI=1S/C23H23N3O5/c1-16(22(27)17-7-4-3-5-8-17)25(2)23(28)24-18-11-13-20(14-12-18)31-21-10-6-9-19(15-21)26(29)30/h3-16,22,27H,1-2H3,(H,24,28)/t16-,22-/m1/s1
PubChem CID	10982716
ChEMBL	CHEMBL311159
IUPHAR	N/A
BindingDB	50101559
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID11428928	BindingDB,ChEMBL

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