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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	CHEMBL134519
Molecular formula	C11H16INO2
IUPAC name	(2R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
Molecular weight	321.158
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.5
Synonyms	(-)-DOI D01TSX ZINC2516053 (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine BDBM50133231 NCGC00162167-01 (R)-DOI R-DOI (2R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine 82864-06-0 GTPL157 (R)-2-(4-Iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine Benzeneethanamine, 4-iodo-2,5-dimethoxy-alpha-methyl-, (alphaR)- PDSP1_001388 SCHEMBL713061 (r)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane AJ-36945 Lopac0_000478 (R)-2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine CCG-204569 PDSP2_001372 [ Show all ]
Inchi Key	BGMZUEKZENQUJY-SSDOTTSWSA-N
Inchi ID	InChI=1S/C11H16INO2/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2/h5-7H,4,13H2,1-3H3/t7-/m1/s1
PubChem CID	9840090
ChEMBL	CHEMBL134519
IUPHAR	157
BindingDB	50133231
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	11.9 nM	PMID16392816, PMID17419053	BindingDB,ChEMBL
EC50	12.0 nM	PMID16392816	BindingDB

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