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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL263141
Molecular formula	C23H35N7O5
IUPAC name	ethyl 3-[4-[5-[(1S)-1-[(2-amino-2-methylpropanoyl)amino]-2-phenylmethoxyethyl]tetrazol-1-yl]butanoylamino]propanoate
Molecular weight	489.577
Hydrogen bond acceptor	9
Hydrogen bond donor	3
XlogP	-0.5
Synonyms	BDBM50376763
Inchi Key	BGFXGXAMAQIXQO-GOSISDBHSA-N
Inchi ID	InChI=1S/C23H35N7O5/c1-4-35-20(32)12-13-25-19(31)11-8-14-30-21(27-28-29-30)18(26-22(33)23(2,3)24)16-34-15-17-9-6-5-7-10-17/h5-7,9-10,18H,4,8,11-16,24H2,1-3H3,(H,25,31)(H,26,33)/t18-/m1/s1
PubChem CID	44450071
ChEMBL	CHEMBL263141
IUPHAR	N/A
BindingDB	50376763
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	140.0 nM	PMID18378446	BindingDB,ChEMBL
Intrinsic activity	<85.0 %	PMID18378446	ChEMBL

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