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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL284213
Molecular formula	C11H12N2S
IUPAC name	5-(4,5,6,7-tetrahydro-1-benzothiophen-4-yl)-1H-imidazole
Molecular weight	204.291
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	2.3
Synonyms	1H-Imidazole, 5-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)- 4-(4,5,6,7-Tetrahydro-benzo[b]thiophen-4-yl)-1H-imidazole 245744-14-3 4,5,6,7-Tetrahydro-4-(1H-imidazole-4-yl)benzo[b]thiophene BDBM50085678
Inchi Key	BFSPTAYUYXLBEU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H12N2S/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1/h4-8H,1-3H2,(H,12,13)
PubChem CID	9815633
ChEMBL	CHEMBL284213
IUPHAR	N/A
BindingDB	50085678
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.56 nM	PMID10715142, PMID10753480	BindingDB,ChEMBL
Ki	0.56 nM	PMID10715142	BindingDB
Ki	27.0 nM	PMID10753480	BindingDB,ChEMBL

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