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GPCR

NameMetabotropic glutamate receptor 1
SpeciesRattus norvegicus (Rat)
GeneGrm1
SynonymmGluR1
SCAR13
mGlu1 receptor
metabotropic glutamate receptor 1
wobl
[ Show all ]
DiseaseN/A for non-human GPCRs
Length1199
Amino acid sequenceMVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
UniProtP23385
Protein Data Bank1iss, 1isr, 1ewk
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 1iss.
BioLiPBL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4477
IUPHAR289
DrugBankN/A

Ligand

NameCHEMBL479804
Molecular formulaC8H14N2O5
IUPAC name(2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioic acid
Molecular weight218.209
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP-3.3
Synonyms(2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioic acid
BDBM50252050
ZINC40933343
(2S,4R)-4-(3-Amino-3-oxopropyl)glutamic acid
Inchi KeyBFKOJIBMYJQCOV-UHNVWZDZSA-N
Inchi IDInChI=1S/C8H14N2O5/c9-5(8(14)15)3-4(7(12)13)1-2-6(10)11/h4-5H,1-3,9H2,(H2,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
PubChem CID24905646
ChEMBLCHEMBL479804
IUPHARN/A
BindingDB50252050
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<100000.0 nMPMID18578478BindingDB,ChEMBL
EC50<1000000.0 nMPMID26814576BindingDB,ChEMBL

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