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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	suloctidil
Molecular formula	C20H35NOS
IUPAC name	(1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol
Molecular weight	337.566
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.8
Synonyms	D05967 MLS002222281 SMR000058933 ZINC2561289 (R,S)-4-((1-Methylethyl)thio)-alpha-(1-(octylamino)ethyl)benzenemethanol BRD-K42635745-001-22-2 HMS2230I12 Opera_ID_1631 ST51015124 (1S,2R)-1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol AC1LCW9C CHEBI:92751 MLS000028666 SBB058183 Suloctidil, analytical standard, for drug analysis (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol BPBio1_000444 cid_657255 GNF-Pf-1859 MLS002695978 SR-01000000281 54767-75-8 BSPBio_000402 HMS3713E04 Prestwick3_000421 (1S,2R)-1-[4-(methylethylthio)phenyl]-2-(octylamino)propan-1-ol AKOS024374991 MLS001148124 SCHEMBL13613541 UNII-XV1N1XY17K component BFCDFTHTSVTWOG-YLJYHZDGSA-N (alphaS)-alpha-[(R)-1-(Octylamino)ethyl]-4-[(1-methylethyl)thio]benzenemethanol BRD-K42635745-001-02-4 CS-4883 HMS2096E04 NCGC00022213-03 SR-01000000281-3 (1S,2R)-1-(4-(isopropylthio)phenyl)-2-(octylamino)propan-1-ol AB00383060 CCG-220421 HY-B1237 REGID_for_CID_657255 Suloctidil (USAN/INN) (1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol BDBM67714 CHEMBL588119 [ Show all ]
Inchi Key	BFCDFTHTSVTWOG-YLJYHZDGSA-N
Inchi ID	InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3/t17-,20-/m1/s1
PubChem CID	657255
ChEMBL	CHEMBL588119
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3446.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	500.7 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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