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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Beta-3 adrenergic receptor
Species	Canis lupus familiaris (Dog)
Gene	ADRB3
Synonym	Beta-3 adrenoceptor Beta-3 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MAPWPHGNGSVASWPAAPTPTPDAANTSGLPGAPWAVALAGALLALEVLATVGGNLLVIVAIARTPRLQTMTNVFVTSLATADLVVGLLVVPPGATLALTGRWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRRARAAVVLVWVVSAAVSFAPIMSKWWRVGADAEAQRCHSNPHCCAFASNIPYALLSSSVSFYLPLLVMLFVYARVFLVATRQLRLLRRELGRFPPAESPPAASRSRSPGPARRCASPAAVPSDRLRPARLLPLREHRALRTLGLIVGTFTLCWLPFFVANVMRALGGPSLVPSPALLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCRREEHRAAASPPGDPSAAPAALTSPAESSRCQALDGASWGIS
UniProt	O02662
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4400
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL270026
Molecular formula	C27H31NO3
IUPAC name	4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-(2-methylpropyl)benzoic acid
Molecular weight	417.549
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	3.1
Synonyms	4''-[2-((R)-2-Hydroxy-2-phenyl-ethylamino)-ethyl]-3-isobutyl-biphenyl-4-carboxylic acid BDBM50236181 SCHEMBL5668838 4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)-10-isobutyl-4-biphenylcarboxylic acid (R)-4''-(2-(2-hydroxy-2-phenylethylamino)ethyl)-3-isobutylbiphenyl-4-carboxylic acid
Inchi Key	NCTDWZFQXDIUEY-SANMLTNESA-N
Inchi ID	InChI=1S/C27H31NO3/c1-19(2)16-24-17-23(12-13-25(24)27(30)31)21-10-8-20(9-11-21)14-15-28-18-26(29)22-6-4-3-5-7-22/h3-13,17,19,26,28-29H,14-16,18H2,1-2H3,(H,30,31)/t26-/m0/s1
PubChem CID	10002049
ChEMBL	CHEMBL270026
IUPHAR	N/A
BindingDB	50236181
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.2 nM	PMID19366244	BindingDB,ChEMBL

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