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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL491221
Molecular formula	C21H25ClN2O2
IUPAC name	N-benzyl-2-(2-chlorophenoxy)-N-[[(2R)-pyrrolidin-2-yl]methyl]propanamide
Molecular weight	372.893
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BDBM50264319 N-benzyl-2-(2-chlorophenoxy)-N-((R)-pyrrolidin-2-ylmethyl)propanamide
Inchi Key	BETCEOCHSYZOAW-UHUGOGIASA-N
Inchi ID	InChI=1S/C21H25ClN2O2/c1-16(26-20-12-6-5-11-19(20)22)21(25)24(15-18-10-7-13-23-18)14-17-8-3-2-4-9-17/h2-6,8-9,11-12,16,18,23H,7,10,13-15H2,1H3/t16?,18-/m1/s1
PubChem CID	44579805
ChEMBL	CHEMBL491221
IUPHAR	N/A
BindingDB	50264319
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	60.0 %	PMID18722770	ChEMBL
EC50	20.0 nM	PMID18722770	BindingDB,ChEMBL

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