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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL489402
Molecular formula	C20H22Cl2N2O2
IUPAC name	2-(3-chlorophenoxy)-N-(2-chlorophenyl)-N-[[(2R)-pyrrolidin-2-yl]methyl]propanamide
Molecular weight	393.308
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.8
Synonyms	BDBM50264487 2-(3-chlorophenoxy)-N-(2-chlorophenyl)-N-((R)-pyrrolidin-2-ylmethyl)propanamide
Inchi Key	BETBBRQIGQOQCK-BZSJEYESSA-N
Inchi ID	InChI=1S/C20H22Cl2N2O2/c1-14(26-17-8-4-6-15(21)12-17)20(25)24(13-16-7-5-11-23-16)19-10-3-2-9-18(19)22/h2-4,6,8-10,12,14,16,23H,5,7,11,13H2,1H3/t14?,16-/m1/s1
PubChem CID	44579881
ChEMBL	CHEMBL489402
IUPHAR	N/A
BindingDB	50264487
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	70.0 %	PMID18722770	ChEMBL
EC50	780.0 nM	PMID18722770	BindingDB,ChEMBL

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