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GPCR

NameN-arachidonyl glycine receptor
SpeciesHomo sapiens (Human)
GeneGPR18
SynonymGPCRW
G-protein coupled receptor 18
N-arachidonoyol glycine receptor
NAGly receptor
GPR18
DiseaseN/A
Length331
Amino acid sequenceMITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
UniProtQ14330
Protein Data BankN/A
GPCR-HGmod modelQ14330
3D structure modelThis predicted structure model is from GPCR-EXP Q14330.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2384898
IUPHAR89
DrugBankBE0002304

Ligand

NameCHEMBL3221196
Molecular formulaC20H18N2O2S
IUPAC name(2Z)-2-[(3-phenoxyphenyl)methylidene]-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]thiazepin-3-one
Molecular weight350.436
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.5
SynonymsN/A
Inchi KeyMVJJGIOLTJZDSD-JXAWBTAJSA-N
Inchi IDInChI=1S/C20H18N2O2S/c23-19-18(21-20-22(19)11-4-5-12-25-20)14-15-7-6-10-17(13-15)24-16-8-2-1-3-9-16/h1-3,6-10,13-14H,4-5,11-12H2/b18-14-
PubChem CID11152300
ChEMBLCHEMBL3221196
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity1.0 %MedChemComm, (2014) 5:5:632ChEMBL
IC5014100.0 nMMedChemComm, (2014) 5:5:632ChEMBL

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