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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Rattus norvegicus (Rat)
Gene	Chrm5
Synonym	cholinergic receptor cholinergic receptor, muscarinic 5 M5 receptor M5R
Disease	N/A for non-human GPCRs
Length	531
Amino acid sequence	MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08911
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL277
IUPHAR	17
DrugBank	N/A

Ligand

Name	CHEMBL6455
Molecular formula	C19H23N3
IUPAC name	4-(2-methyl-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinolin-7-yl)aniline
Molecular weight	293.414
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.4
Synonyms	SCHEMBL10706062 BDBM50028297 cis-4-(2-Methyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinolin-7-yl)-phenylamine
Inchi Key	MQYSOFADODEXLT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23N3/c1-21-10-11-22-12-18(14-6-8-15(20)9-7-14)16-4-2-3-5-17(16)19(22)13-21/h2-9,18-19H,10-13,20H2,1H3
PubChem CID	13457932
ChEMBL	CHEMBL6455
IUPHAR	N/A
BindingDB	50028297
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4000.0 nM	PMID6747997	BindingDB,ChEMBL

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