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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL1165765
Molecular formula	C37H49N9O7S2
IUPAC name	(4R,7S,10S,13S,16S,19R)-19-acetamido-10-(4-aminobutyl)-16-benzyl-13-(1H-indol-3-ylmethyl)-7-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Molecular weight	795.975
Hydrogen bond acceptor	10
Hydrogen bond donor	9
XlogP	0.4
Synonyms	Ac-[CFWKAC]-NH2 BDBM50320473
Inchi Key	MOJPOINJDNAUNK-RBKWUFDTSA-N
Inchi ID	InChI=1S/C37H49N9O7S2/c1-21-33(49)46-30(32(39)48)19-54-55-20-31(42-22(2)47)37(53)44-28(16-23-10-4-3-5-11-23)35(51)45-29(17-24-18-40-26-13-7-6-12-25(24)26)36(52)43-27(34(50)41-21)14-8-9-15-38/h3-7,10-13,18,21,27-31,40H,8-9,14-17,19-20,38H2,1-2H3,(H2,39,48)(H,41,50)(H,42,47)(H,43,52)(H,44,53)(H,45,51)(H,46,49)/t21-,27-,28-,29-,30-,31-/m0/s1
PubChem CID	10887289
ChEMBL	CHEMBL1165765
IUPHAR	N/A
BindingDB	50320473
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	50.0 %	PMID20043680	ChEMBL
Ki	<10000.0 nM	PMID20043680	BindingDB,ChEMBL

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