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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Galanin receptor type 1
Species	Homo sapiens (Human)
Gene	GALR1
Synonym	GAL1-R GALNR GALNR1 GALR-1 GAL1 receptor
Disease	Epileptic seizures
Length	349
Amino acid sequence	MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProt	P47211
Protein Data Bank	N/A
GPCR-HGmod model	P47211
3D structure model	This predicted structure model is from GPCR-EXP P47211.
BioLiP	N/A
Therapeutic Target Database	T78581
ChEMBL	CHEMBL4894
IUPHAR	243
DrugBank	N/A

Ligand

Name	CHEMBL1922022
Molecular formula	C26H27FN8O2
IUPAC name	4-N-(3-fluoro-4-methoxyphenyl)-2-N-(4-methoxyphenyl)-6-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidine-2,4-diamine
Molecular weight	502.554
Hydrogen bond acceptor	11
Hydrogen bond donor	2
XlogP	4.7
Synonyms	BDBM50358670 SCHEMBL10143488
Inchi Key	MGOYDGQTNJPALW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27FN8O2/c1-36-20-7-4-18(5-8-20)31-25-32-23(30-19-6-9-22(37-2)21(27)16-19)17-24(33-25)34-12-14-35(15-13-34)26-28-10-3-11-29-26/h3-11,16-17H,12-15H2,1-2H3,(H2,30,31,32,33)
PubChem CID	57395996
ChEMBL	CHEMBL1922022
IUPHAR	N/A
BindingDB	50358670
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3840.0 nM	PMID22018787	BindingDB,ChEMBL
Inhibition	60.0 %	PMID22018787	ChEMBL

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