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GPCR

NameKappa-type opioid receptor
SpeciesCavia porcellus (Guinea pig)
GeneOPRK1
SynonymK-OR-1
KOR-1
DiseaseN/A for non-human GPCRs
Length380
Amino acid sequenceMGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
UniProtP41144
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3952
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL610539
Molecular formulaC38H43N3O5
IUPAC namebenzyl (1S,2S,7R,12R,17R,25R)-26-(cyclopropylmethyl)-2,20-dihydroxy-15-methyl-18-oxa-9,15,26-triazaoctacyclo[17.9.1.01,17.02,25.04,16.05,14.07,12.023,29]nonacosa-4(16),5(14),19,21,23(29)-pentaene-9-carboxylate
Molecular weight621.778
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP4.3
SynonymsN/A
Inchi KeyBCPUGGCDIQTIQA-NDKXRCAUSA-N
Inchi IDInChI=1S/C38H43N3O5/c1-39-29-16-24-11-13-41(36(43)45-21-23-5-3-2-4-6-23)20-26(24)15-27(29)28-18-38(44)31-17-25-9-10-30(42)34-32(25)37(38,35(46-34)33(28)39)12-14-40(31)19-22-7-8-22/h2-6,9-10,22,24,26,31,35,42,44H,7-8,11-21H2,1H3/t24-,26+,31-,35+,37+,38-/m1/s1
PubChem CID46877651
ChEMBLCHEMBL610539
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC501.6 nMPMID8360887ChEMBL

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