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Name | Oxoeicosanoid receptor 1 |
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Species | Homo sapiens (Human) |
Gene | OXER1 |
Synonym | R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 [ Show all ] |
Disease | N/A |
Length | 423 |
Amino acid sequence | MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG |
UniProt | Q8TDS5 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDS5 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDS5. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1628461 |
IUPHAR | 271 |
DrugBank | N/A |
Name | 5-Oxo-ETE |
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Molecular formula | C20H30O3 |
IUPAC name | (6E,8Z,11Z,14Z)-5-oxoicosa-6,8,11,14-tetraenoic acid |
Molecular weight | 318.457 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | 5-oxo-6,8,11,14-eicosatetraenoate AC1NR1NN CHEMBL18028 HMS1989I15 SCHEMBL139762 [ Show all ] |
Inchi Key | MEASLHGILYBXFO-XTDASVJISA-N |
Inchi ID | InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+ |
PubChem CID | 5283159 |
ChEMBL | CHEMBL18028 |
IUPHAR | 3391, 3416 |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 3.1 - 5.0 nM | PMID7797484, PMID19450703, PMID18292294, PMID9829988, PMID1326548 | IUPHAR |
EC50 | 7.0 nM | PMID21316960 | ChEMBL |
EC50 | 67.0 nM | MedChemComm, (2012) 3:2:195 | ChEMBL |
IC50 | 3.0 nM | PMID21377873 | ChEMBL |
Kd | 3.8 nM | PMID9829988 | IUPHAR |
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