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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Ligand

NameBDBM50442557
Molecular formulaC82H112N18O16
IUPAC nameN-[2-[2-aminoethyl-[2-[[4-[2-[2-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethylamino]-4-oxobutanoyl]amino]ethyl]amino]ethyl]-N'-[2-[2-[2-[[N'-[(4R)-4-[(2,2-diphenylacetyl)amino]-5-[(4-hydroxyphenyl)methylamino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethyl]butanediamide
Molecular weight1605.91
Hydrogen bond acceptor20
Hydrogen bond donor17
XlogP1.4
SynonymsN/A
Inchi KeyMDRUGETYAVKWAV-OQFFVEAFSA-N
Inchi IDInChI=1S/C82H112N18O16/c83-37-46-100(47-40-86-69(103)33-35-71(105)88-42-49-113-53-55-115-51-44-92-81(111)98-79(84)90-38-13-23-67(75(107)94-57-59-25-29-65(101)30-26-59)96-77(109)73(61-15-5-1-6-16-61)62-17-7-2-8-18-62)48-41-87-70(104)34-36-72(106)89-43-50-114-54-56-116-52-45-93-82(112)99-80(85)91-39-14-24-68(76(108)95-58-60-27-31-66(102)32-28-60)97-78(110)74(63-19-9-3-10-20-63)64-21-11-4-12-22-64/h1-12,15-22,25-32,67-68,73-74,101-102H,13-14,23-24,33-58,83H2,(H,86,103)(H,87,104)(H,88,105)(H,89,106)(H,94,107)(H,95,108)(H,96,109)(H,97,110)(H4,84,90,92,98,111)(H4,85,91,93,99,112)/t67-,68-/m1/s1
PubChem CID91898589
ChEMBLN/A
IUPHARN/A
BindingDB50442557
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki<5000.0 nMPMID24074877BindingDB

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