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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid
Molecular formula	C8H10N2O2
IUPAC name	4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid
Molecular weight	166.18
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.3
Synonyms	6076-13-7 AJ-56340 BS-3906 EC-000.1365 HMS1378G20 LWXNHFZBFJMHGU-UHFFFAOYSA-N SMR000012294 Z359419742 4,5,6,7-tetrahydro-1 h-indazole-3-carboxylic acid 4,5,6,7-TETRAHYDRO-2H-INDAZOLE-3-CARBOXYLIC ACID 95% AB0162406 ALBB-008809 ChemDiv2_003320 EU-0066595 HTS001527 MolPort-000-149-162 ST4140398 1H-4,5,6,7-tetrahydroindazole-3-carboxylic acid 4,5,6,7-Tetrahydroindazole-3-carboxylic acid AC1Q72Q0 BBL001463 DA-03992 FT-0645541 KB-35538 SBB010475 W-9867 2H-Indazole-3-carboxylicacid, 4,5,6,7-tetrahydro- 714255-28-4 AKOS000271448 EG-0015 HMS2188P17 MCULE-4145106491 SR-01000597147 ZINC6529827 4,5,6,7-Tetrahydro-2H-indazole-3-carboxylic acid, AldrichCPR AC-22874 BAS 03395076 CTK2H6469 F0917-7549 I14-3011 MolPort-000-767-792 STK391766 1H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro- AC1Q748E BDBM50132142 DTXSID00349466 FT-0692366 KS-000023JS SCHEMBL1808017 Z-0201 2H-Indazole-3-carboxylicacid,4,5,6,7-tetrahydro- 4,5,6,7-Tetrahydro-2H-indazole-3-carboxylic acid AB00410421-04 AKOS005350674 CHEMBL338405 EN300-33435 HTS000434 MLS000074645 SR-01000597147-1 ZX-CM014967 4,5,6,7-Tetrahydroindazol-3-carbonsaure AC1LDJ0A BB 0219044 D06UZK F1907-0089 KB-35532 Oprea1_089683 TR-020945 2H-Indazole-3-carboxylic acid, 4,5,6,7-tetrahydro- [ Show all ]
Inchi Key	LWXNHFZBFJMHGU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H10N2O2/c11-8(12)7-5-3-1-2-4-6(5)9-10-7/h1-4H2,(H,9,10)(H,11,12)
PubChem CID	648852
ChEMBL	CHEMBL338405
IUPHAR	N/A
BindingDB	50132142
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	29.0 %	PMID18983141	ChEMBL
Ki	3540.0 nM	PMID12930155	BindingDB,ChEMBL

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