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GPCR

NameAlpha-2A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA2A
SynonymAlpha-2A adrenoceptor
Alpha-2A adrenoreceptor
Alpha-2AAR
Alpha-2D adrenergic receptor
DiseaseN/A for non-human GPCRs
Length452
Amino acid sequenceMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtQ28838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4744
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL284912
Molecular formulaC21H34N2O3
IUPAC name5-methoxy-N-(4-morpholin-4-ylbutyl)-N-propyl-3,4-dihydro-2H-chromen-3-amine
Molecular weight362.514
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.3
SynonymsBDBM50036858
(5-Methoxy-chroman-3-yl)-(4-morpholin-4-yl-butyl)-propyl-amine
Inchi KeyLUDDDWQEQCANFX-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H34N2O3/c1-3-9-23(11-5-4-10-22-12-14-25-15-13-22)18-16-19-20(24-2)7-6-8-21(19)26-17-18/h6-8,18H,3-5,9-17H2,1-2H3
PubChem CID9975915
ChEMBLCHEMBL284912
IUPHARN/A
BindingDB50036858
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC504000.0 nMPMID7912735BindingDB,ChEMBL

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