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GPCR

NameMetabotropic glutamate receptor 1
SpeciesHomo sapiens (Human)
GeneGRM1
SynonymSCAR13
MGLUR1
mGlu1 receptor
metabotropic glutamate receptor 1
GPRC1A
[ Show all ]
DiseaseAlzheimer disease; Huntington's disease
Neurological disease
Neuropathic pain
Schizophrenia
Pain
Length1194
Amino acid sequenceMVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
UniProtQ13255
Protein Data Bank4or2, 3ks9
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4or2.
BioLiPBL0271871,BL0271876, BL0271872,BL0271873,BL0271874,, BL0174211,BL0174213, BL0174210,BL0174212
Therapeutic Target DatabaseT27137
ChEMBLCHEMBL3772
IUPHAR289
DrugBankBE0000824

Ligand

NameCHEMBL40123
Molecular formulaC19H21NO4
IUPAC name(2S,4S)-2-amino-4-(2,2-diphenylethyl)pentanedioic acid
Molecular weight327.38
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP0.3
Synonyms2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid
(2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid
ZINC13797034
(2S,4S)-2-amino-4-(2,2-diphenylethyl)pentanedioic Acid
BDBM50069111
[ Show all ]
Inchi KeyLSXSDBGWRLZZIR-RDJZCZTQSA-N
Inchi IDInChI=1S/C19H21NO4/c20-17(19(23)24)12-15(18(21)22)11-16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-17H,11-12,20H2,(H,21,22)(H,23,24)/t15-,17-/m0/s1
PubChem CID10359073
ChEMBLCHEMBL40123
IUPHARN/A
BindingDB50069111
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<300000.0 nMPMID9871538BindingDB,ChEMBL
Ki<300000.0 nMPMID10893301BindingDB,ChEMBL

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