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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL236396
Molecular formula	C31H35N3O3
IUPAC name	N-methyl-1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]-4-phenyl-N-(2-phenylethyl)piperidine-4-carboxamide
Molecular weight	497.639
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.5
Synonyms	N-methyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)-N-phenethyl-4-phenylpiperidine-4-carboxamide SCHEMBL4430397 BDBM50224720
Inchi Key	LDGQXFYTLVIEGL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H35N3O3/c1-32(19-16-25-10-4-2-5-11-25)30(36)31(26-12-6-3-7-13-26)17-20-33(21-18-31)22-23-34-27-14-8-9-15-28(27)37-24-29(34)35/h2-15H,16-24H2,1H3
PubChem CID	24803165
ChEMBL	CHEMBL236396
IUPHAR	N/A
BindingDB	50224720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	12000.0 nM	PMID17933531	BindingDB,ChEMBL

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