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GPCR

NameThromboxane A2 receptor
SpeciesMus musculus (Mouse)
GeneTbxa2r
SynonymProstanoid TP receptor
TP receptor
TXA2-R
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
UniProtP30987
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795181
IUPHAR346
DrugBankN/A

Ligand

NameCHEMBL2315059
Molecular formulaC26H17Cl4FN2O4S
IUPAC name6-[[5-chloro-2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]methyl]-N-(3,4-dichlorophenyl)sulfonylpyridine-2-carboxamide
Molecular weight614.29
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP7.6
SynonymsBDBM50424381
Inchi KeyLDFRXJWXVDCNFQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H17Cl4FN2O4S/c27-17-6-9-25(37-14-15-4-5-18(28)12-23(15)31)16(10-17)11-19-2-1-3-24(32-19)26(34)33-38(35,36)20-7-8-21(29)22(30)13-20/h1-10,12-13H,11,14H2,(H,33,34)
PubChem CID71517032
ChEMBLCHEMBL2315059
IUPHARN/A
BindingDB50424381
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID23218714ChEMBL

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