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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL501794
Molecular formula	C54H75N11O10S2
IUPAC name	(2S)-2-[[(4R,7S,10S,13S,16S,19S)-10-(4-aminobutyl)-16-benzyl-19-[[(2S)-2,6-diaminohexanoyl]amino]-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
Molecular weight	1102.38
Hydrogen bond acceptor	15
Hydrogen bond donor	13
XlogP	0.6
Synonyms	BDBM50413775
Inchi Key	KXOUSQMYOTXSID-CUBAGAGOSA-N
Inchi ID	InChI=1S/C54H75N11O10S2/c1-31(2)44(53(74)75)64-51(72)43-30-76-77-54(3,4)45(65-46(67)37(57)17-10-12-24-55)52(73)62-41(26-32-14-6-5-7-15-32)48(69)61-42(28-34-29-58-38-18-9-8-16-36(34)38)50(71)59-39(19-11-13-25-56)47(68)60-40(49(70)63-43)27-33-20-22-35(66)23-21-33/h5-9,14-16,18,20-23,29,31,37,39-45,58,66H,10-13,17,19,24-28,30,55-57H2,1-4H3,(H,59,71)(H,60,68)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,67)(H,74,75)/t37-,39-,40-,41-,42-,43-,44-,45-/m0/s1
PubChem CID	44574158
ChEMBL	CHEMBL501794
IUPHAR	N/A
BindingDB	50413775
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6.026 nM	PMID19432421	ChEMBL
EC50	6.03 nM	PMID19432421	BindingDB

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