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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL423891
Molecular formula	C20H20N4O
IUPAC name	2-[4-[(E)-3-phenylprop-2-enoyl]piperazin-1-yl]-2-pyridin-3-ylacetonitrile
Molecular weight	332.407
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.0
Synonyms	BDBM50003549 SCHEMBL9852998 2-[4-(3-Phenyl-1-oxo-2-propenyl)-1-piperazinyl]-2-(3-pyridinyl)acetonitrile [4-(3-Phenyl-acryloyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile
Inchi Key	KWLHBPRKPZDBEA-CMDGGOBGSA-N
Inchi ID	InChI=1S/C20H20N4O/c21-15-19(18-7-4-10-22-16-18)23-11-13-24(14-12-23)20(25)9-8-17-5-2-1-3-6-17/h1-10,16,19H,11-14H2/b9-8+
PubChem CID	9996872
ChEMBL	CHEMBL423891
IUPHAR	N/A
BindingDB	50003549
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.24 mg.kg-1	PMID1433215	ChEMBL

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