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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	1H-Pyrazole-3-carboxylic acid
Molecular formula	C4H4N2O2
IUPAC name	1H-pyrazole-5-carboxylic acid
Molecular weight	112.088
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.1
Synonyms	MLS001048880 3-pyrazole carboxylic acid pyrazole 3-carboxylic acid 643P753 RP00549 AC1LCCJ7 SC-69621 AKOS000189249 TR-032067 ANW-49655 zlchem 656 BH802 CS-10742 F3250-0675 KB-265580 1H-Pyrazole-5-carboxylic acid 2H-Pyrazole-3-carboxylic acid, AldrichCPR NCGC00246284-01 4CH-003649 Pyrazole-5-carboxylic acid AB00698081-04 S04-0043 ACMC-209z0p ST005603 AM20080446 VU0607310-1 BC203654 CTK5E7038 FT-0647740 1-H-pyrazole-3-carboxylic acid KS-000003T3 MCULE-5843831241 3-carboxy-1h-pyrazole PS-3789 5053AH Pyrazolic acid AB1001472 SBB000005 AJ-53820 SY002921 AN-27234 ZERO/001694 BCP9000066 CM11038 EC-000.1960 InChI=1/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8 1H-Pyrazole-5-carboxylic acid # MolPort-000-149-308 3-Pyrazolecarboxylic acid Pyrazole-3-carboxylic acid 797027-83-9 RP19038 AC1Q5UBI SCHEMBL7790 AKOS000300717 TRA0072546 BB 0219085 ZLD0106 BR-29904 CS-W002328 FC0938 KB-60075 2H-PYRAZOLE-3-CARBOXYLICACID P1862 5-Pyrazolecarboxylic acid pyrazolecarboxylic AB00698081-05 S14-2355 ACN-P000884 ST2408926 AM804418 W-205899 BCP11490 CHEMBL128679 D0M7DC HMS2267D14 1621-91-6 KSC174G4J MFCD00077436 3-Carboxypyrazole PubChem12935 621P916 R345 AC-1719 SC-20998 AK-29904 TPC-I149 ANW-21979 ZINC5324338 BDBM50132132 CP-371 EN300-37077 Jsp003249 1H-Pyrazole-3-carboxylic acid, 97% 2H-PYRAZOLE-3-CARBOXYLIC ACID MolPort-000-158-417 3-Pyrazolecarboxylic acid, 97% pyrazole-5-carboxylic AB0018116 RTR-032067 AC1Q7486 SMR000387081 ALBB-006075 VP20154 BBL009183 C-5615 CTK0H4344 FT-0083397 KOPFEFZSAMLEHK-UHFFFAOYSA-N L-4524 2H-Pyrazole-5-carboxylic acid PB17100 pyrazolecarboxylic acid AB06191 SB10560 ACT05688 STK257453 AN-14646 Z381357668 BCP26785 CL3512 DB-005733 HTS000641 1H-pyrazol-3-carboxylic acid [ Show all ]
Inchi Key	KOPFEFZSAMLEHK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8)
PubChem CID	574310
ChEMBL	CHEMBL128679
IUPHAR	N/A
BindingDB	50132132
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	594.0 nM	PMID12930155	BindingDB,ChEMBL

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