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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(4) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd4
Synonym	D(2C) dopamine receptor D4 receptor D4R Dopamine D4 receptor dopamine receptor 4
Disease	N/A for non-human GPCRs
Length	387
Amino acid sequence	MGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProt	P30729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3361
IUPHAR	217
DrugBank	N/A

Ligand

Name	Homocysteine thiolactone
Molecular formula	C4H7NOS
IUPAC name	(3S)-3-aminothiolan-2-one
Molecular weight	117.166
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	-0.1
Synonyms	L-Homocysteine thiolactone (3S)-3-aminothiolan-2-one CAS_134505 FCH932421 PDSP2_001257 06DCC220-D06A-4793-8958-6383A1C2218C AJ-112267 KB-211461 UNII-D5H88XF24X component KIWQWJKWBHZMDT-VKHMYHEASA-N 2(3H)-Thiophenone, 3-aminodihydro-, (S)- AX8133745 NSC_134505 (S)-3-aminodihydro-2(3H)-thiophenone AC1L34Q6 CHEBI:60315 S502 10593-85-8 AK116252 KIWQWJKWBHZMDT-VKHMYHEASA-N ZINC54009855 (3S)-3-aminodihydrothiophen-2(3H)-one 2338-04-7 BDBM86198 PDSP1_001273 (S)-3-Aminodihydrothiophen-2(3H)-one AC1Q6HVW CTK8E0354 homocysteine thiolactone hydrochloride SCHEMBL2167191 1317AA AKOS006240739 [ Show all ]
Inchi Key	KIWQWJKWBHZMDT-VKHMYHEASA-N
Inchi ID	InChI=1S/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m0/s1
PubChem CID	134505
ChEMBL	N/A
IUPHAR	N/A
BindingDB	86198
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID12649361	BindingDB

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