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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	SCHEMBL4802295
Molecular formula	C22H27N3O3S3
IUPAC name	N-[5-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-5-(5-methylthiophen-2-yl)thiophene-2-sulfonamide
Molecular weight	477.656
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.5
Synonyms	CHEMBL2364421
Inchi Key	AXIMEHSTRHVITG-GASCZTMLSA-N
Inchi ID	InChI=1S/C22H27N3O3S3/c1-14-12-25(13-15(2)23-14)17-6-7-19(28-4)18(11-17)24-31(26,27)22-10-9-21(30-22)20-8-5-16(3)29-20/h5-11,14-15,23-24H,12-13H2,1-4H3/t14-,15+
PubChem CID	69197133
ChEMBL	CHEMBL2364421
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	25.12 nM	DOI: http://dx.doi.org/10.6019/CHEMBL2364335	ChEMBL

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