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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL235012
Molecular formula	C19H25N7O3
IUPAC name	methyl 3-[5-[(1R)-1-[(2-amino-2-methylpropanoyl)amino]-2-(1H-indol-3-yl)ethyl]tetrazol-1-yl]propanoate
Molecular weight	399.455
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	0.3
Synonyms	BDBM50222138 (R)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2-(1H-indol-3-yl)ethyl)-1H-tetrazol-1-yl)propanoate
Inchi Key	AWZYAFVOPINYSN-OAHLLOKOSA-N
Inchi ID	InChI=1S/C19H25N7O3/c1-19(2,20)18(28)22-15(10-12-11-21-14-7-5-4-6-13(12)14)17-23-24-25-26(17)9-8-16(27)29-3/h4-7,11,15,21H,8-10,20H2,1-3H3,(H,22,28)/t15-/m1/s1
PubChem CID	44434018
ChEMBL	CHEMBL235012
IUPHAR	N/A
BindingDB	50222138
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	200.0 nM	PMID17869100	BindingDB,ChEMBL
Ki	<5000.0 nM	PMID17869100	BindingDB,ChEMBL

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