Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Beta-1 adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRB1
Synonym	Adrenergic receptor beta 1 Adrb-1 ADRB1R adrenergic receptor beta 1-AR beta1-adrenoceptor beta-1 adrenoreceptor Beta-1 adrenoceptor B1AR beta-1 adrenergic receptor [ Show all ]
Disease	Heart failure; Cardiogenic shock Heart failure Glaucoma Diabetes Coronary artery disease Circulatory disorders Chronic open-angle glaucoma; Ocular hypertension Chronic open-angle glaucoma High blood pressure High blood pressure; Angina Hypertension Septic shock; Neurogenic shock Open-angle glaucoma; Ocular hypertension Migraine Maintenance of normal sinus rhythm Hypertension; Ventricular premature beats Hypertension; Heart arrhythmia Hypertension; Angina pectoris Hypertension; Angina Ventricular fibrillation Central and peripheral nervous diseases Acute supraventricular tachycardia Open-angle glaucoma Allergy; Sepsis Angina pectoris Angina pectoris; Hypertension Bronchodilator Cardiac arrhythmias [ Show all ]
Length	477
Amino acid sequence	MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
UniProt	P08588
Protein Data Bank	N/A
GPCR-HGmod model	P08588
3D structure model	This predicted structure model is from GPCR-EXP P08588.
BioLiP	N/A
Therapeutic Target Database	T44068
ChEMBL	CHEMBL213
IUPHAR	28
DrugBank	BE0000172

Ligand

Name	isoproterenol
Molecular formula	C11H17NO3
IUPAC name	4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
Molecular weight	211.261
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-0.6
Synonyms	Isupren WIN 5162 KBioGR_000427 LS-42868 NCGC00015558-04 NCGC00015558-12 NINDS_000894 NSC9975 Protocatechuyl alcohol, alpha-(isopropylaminomethyl)- SBI-0050689.P004 Isoproterenol; Spectrum5_000880 dl-Isopropylnoradrenaline 3,4-dihydroxy-alpha-[(isopropylamino)methyl]-benzyl alcohol EN300-148243 4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;hydrochloride IDI1_000894 6700-39-6 Isoprenaline AC1Q1QBS Isopropyl noradrenaline API0006523 Isoproterenol (-) Benzyl alcohol, 3,4-dihydroxy-.alpha.-((isopropylamino)methyl)- C07056 (.+/-.)-Isoprenaline d-Isoprenaline .alpha.-(Isopropylaminomoethyl)protocatechuyl alcohol 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- STL558077 KBio1_000894 l-Isoproterenol Medihaler-ISO NCGC00015558-07 NCGC00025274-03 NSC 33791 PDSP2_001409 Racemic isoprenaline SPBio_001042 Isorenin DSSTox_CID_3175 4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol FT-0724367 4-{1-hydroxy-2-[(methylethyl)amino]ethyl}benzene-1,2-diol Isonorene AB00053487-09 Isoprenalinesulphate Aleudrine Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol Asmalar Isoproterenol,(+) BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, (+-)- (+)-Isoproterenol CCG-204796 (S)-(+)-Isoproterenol d-N-Isopropylnorepinephrine 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- (9CI) DivK1c_000894 149-53-1 Isuprel (TN) to_000062 KBio2_006565 Lopac0_000711 N-Isopropylnoradrenaline NCGC00015558-10 neo-Epinine NSC-9975 Prestwick2_001097 Saventrine Spectrum3_000474 3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol DTXSID4023175 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol # I14-45263 46388-38-9 Isoprenalina AB00053487_12 ISOPROP Aludrin Isopropylnorepinephrine BDBM25392 Bronkephrine (+/-)-isoprenaline D0IF0C 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)- dl-Ipr Izadrin (Salt/Mix) WLN: QR BQ DYQ1MY1&1 KBioSS_001429 LS-42869 NCGC00015558-05 NCGC00015558-14 Norisodrine Oprea1_009434 Protocatechuyl alcohol,- SCHEMBL4165 Isoproterenolum Spectrum_000949 DL-Isopropylnorepinephrine 3,4-dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol Epinephrine isopropyl homolog 4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol Isadrin 683I592 Isoprenaline (INN) AKOS015913894 Isopropyladrenaline AS1409 Isoproterenol Chloride Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)- CAS-7683-59-2 (.+/-.)-Isoproterenol d-Isopropylarterenol 1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- DB01064 1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol Tox21_110172 KBio2_001429 L000936 N-Isopropyl-.beta.-dihydroxyphenyl-.beta.-hydroxyethylamine NCGC00015558-08 NCGC00025274-04 NSC 9975 Prestwick0_001097 Racemic isoproterenol SPBio_003057 Isuprel DSSTox_GSID_23175 4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol GTPL536 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol Isonorin AB00053487-10 Isoprenalinum alpha-(Isopropylaminomethyl)protocatechuyl alcohol Isopropylarterenol Assiprenol Isoproterenol-l Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]- (+-)-Isoprenaline CCRIS 3081 (S)-Isoprenaline D08090 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-(9CI) DL(+-)-Isoproterenol Isuprel Mistometer Vapo-N-iso KBio3_001428 LS-42866 N-Isopropylnorepinephrine NCGC00015558-11 Neodrenal NSC33791 Proternol SBB005855 Spectrum4_000024 3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol EINECS 231-687-7 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol ICI 46399 Isoprenalina [INN-Spanish] AC1L1GOZ Isopropydrin Aludrine Bellasthman BSPBio_002208 (+/-)-isoproterenol CHEMBL434 .alpha.-(Isopropylaminomethyl)protocatechuyl alcohol D0P1IS 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)-(9CI) dl-Isadrine ST077771 JWZZKOKVBUJMES-UHFFFAOYSA-N l-Isopropylnoradrenaline MCULE-6061231962 NCGC00015558-06 NCGC00016665-02 Novodrin PDSP1_001425 Protocatechuyl alcohol,.alpha.-(isopropylamino-methyl),- SGCUT00015 ISOPROTERONOL dl-N-Isopropylnoradrenaline 3-13-00-02387 (Beilstein Handbook Reference) Euspiran (Salt/Mix) 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol Isadrine 7683-59-2 Isoprenaline [INN] Aleudrin Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol Asiprenol Isoproterenol [JAN] BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((ISOPROPYLAMINO)METHYL)-, (+)- (+)-Isoprenaline CCG-204727 (A+/-)-Isoproterenol hydrochloride d-Isoproterenol 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- Dihydroxyphenylethanolisopropylamine 1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol Tox21_110172_1 KBio2_003997 Lomupren N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine NCGC00015558-09 NCGC00162220-01 NSC-33791 Prestwick1_001097 Respifral Spectrum2_001061 Isuprel (Salt/Mix) 3,4-Dihydroxy-.alpha.-(isopropylaminomethyl)-benzyl alcohol DSSTox_RID_76904 4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol HMS2089A12 4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol, 2 Isoprenalin AB00053487_11 Isoprenalinum [INN-Latin] alpha-(Isopropylaminomoethyl)protocatechuyl alcohol Isopropylnoradrenaline BCP09043 BRN 2213857 (+-)-Isoproterenol CHEBI:64317 (S)-Isoproterenol D0I8FI 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (+-)- DL(.+/-.)-Isoproterenol [ Show all ]
Inchi Key	JWZZKOKVBUJMES-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
PubChem CID	3779
ChEMBL	CHEMBL434
IUPHAR	536
BindingDB	25392
DrugBank	DB01064
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	0.084 nM	PMID18307290, PMID15603933, PMID18651730, PMID18553954	BindingDB
EC50	0.084 nM	PMID18307290, PMID15603933, PMID18752946, PMID18651730, PMID18553954	BindingDB,ChEMBL
EC50	0.84 nM	PMID19366244	BindingDB
EC50	0.84 nM	PMID19366244	ChEMBL
EC50	1.0 nM	PMID16640337, PMID11806709	BindingDB,ChEMBL
EC50	7.9 nM	PMID19317397, PMID21696967, PMID21925889, PMID20462258	BindingDB
EC50	7.943 nM	PMID19317397, PMID21696967, PMID21925889, PMID20462258	ChEMBL
EC50	12.0 nM	PMID19232786, PMID19581100	BindingDB,ChEMBL
EC50	100.0 nM	PMID19362005	BindingDB,ChEMBL
EC50	1000.0 nM	PMID19581100	BindingDB,ChEMBL
Emax	109.0 %	PMID16640337, PMID11806709	ChEMBL
IA	100.0 -	PMID10691685	ChEMBL
IC50	333.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Intrinsic activity	1.0 -	PMID19232786	ChEMBL
Intrinsic activity	100.0 -	PMID10377236	ChEMBL
Ki	100.0 - 251.189 nM	PMID8982677, PMID2849109	IUPHAR
Ki	193.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	224.0 nM	PMID14730417	BindingDB
Ki	1584.89 nM	PMID10377236	ChEMBL
pK	8.81 -	PMID10691685	ChEMBL
pKact	8.75 -	PMID10377236	ChEMBL

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417