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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL1165793
Molecular formula	C41H50N8O8S2
IUPAC name	(4R,7S,10S,13S,16S,19R)-19-amino-10-(4-aminobutyl)-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxylic acid
Molecular weight	847.019
Hydrogen bond acceptor	12
Hydrogen bond donor	10
XlogP	-0.2
Synonyms	CFWKYC BDBM50320465
Inchi Key	JSYDWSHWYSGRFQ-LXOXETEGSA-N
Inchi ID	InChI=1S/C41H50N8O8S2/c42-17-7-6-12-31-37(52)47-33(19-25-13-15-27(50)16-14-25)39(54)49-35(41(56)57)23-59-58-22-29(43)36(51)46-32(18-24-8-2-1-3-9-24)38(53)48-34(40(55)45-31)20-26-21-44-30-11-5-4-10-28(26)30/h1-5,8-11,13-16,21,29,31-35,44,50H,6-7,12,17-20,22-23,42-43H2,(H,45,55)(H,46,51)(H,47,52)(H,48,53)(H,49,54)(H,56,57)/t29-,31-,32-,33-,34-,35-/m0/s1
PubChem CID	11714850
ChEMBL	CHEMBL1165793
IUPHAR	N/A
BindingDB	50320465
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.6 nM	PMID20043680	BindingDB,ChEMBL

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