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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Platelet-activating factor receptor
Species	Mus musculus (Mouse)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProt	Q62035
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3993
IUPHAR	334
DrugBank	N/A

Ligand

Name	CHEMBL134143
Molecular formula	C27H25N3O
IUPAC name	2-[1-(3,3-diphenylpropanoyl)piperidin-4-ylidene]-2-pyridin-3-ylacetonitrile
Molecular weight	407.517
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.8
Synonyms	BDBM50003485 SCHEMBL9852889 2-[1-(3,3-Diphenylpropionyl)piperidin-4-ylidene]-2-(3-pyridinyl)acetonitrile [1-(3,3-Diphenyl-propionyl)-piperidin-4-ylidene]-pyridin-3-yl-acetonitrile; hydrate
Inchi Key	JSIZGZYXULERFB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H25N3O/c28-19-26(24-12-7-15-29-20-24)23-13-16-30(17-14-23)27(31)18-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,20,25H,13-14,16-18H2
PubChem CID	14966970
ChEMBL	CHEMBL134143
IUPHAR	N/A
BindingDB	50003485
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	30.0 mg.kg-1	PMID1433215	ChEMBL

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