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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	terguride
Molecular formula	C20H28N4O
IUPAC name	3-[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
Molecular weight	340.471
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.5
Synonyms	85649-11-2 BDBM50017519 D01348 FT-0667042 N,N-Dethyl-n'-[(8alpha)-6-methylergoln-8-yl]urea Prestwick1_000945 SCHEMBL147259 Tergurida trans-Dihydro Lisuride 21OJT43Q88 ZK-31224 9,10\|A-Dihydrolisuride BSPBio_000834 DSSTox_CID_25809 HMS2232H10 N,N-Diethyl-N'-[(8\|A)-6-methylergolin-8-yl]urea S(+)-N,N-Diethyl-N inverted exclamation marka([8\|A]-6-methylergolin-8-yl)urea SPBio_003069 Terguride (JAN/INN) (5R,8S,10R)-Terguride UNII-21OJT43Q88 37686-85-4 (maleate[1:1]) 6-Methyl-8alpha-(diethylcarbamoylamino)ergoline AJ-45674 DTXSID3045809 KS-1464 Opera_ID_1172 S(+)-Terguride Teluron (TN) Terguridum [Latin] 1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-yl)-urea ZINC3811327 8alpha-(3,3-diethylureido)-6-methylergoline BPBio1_000918 D01ZOB GTPL56 N,N-Diethyl-N'-(D-6-methyl-10alpha-isoergolin-8-yl)urea Prestwick2_000945 SH-406 Tergurida [Spanish] (+)-(5R,8S,10R)-Terguride trans-Dihydrolisuride 3-[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-1,1-diethylurea AB00514698 CAS-37686-84-3 DSSTox_GSID_45809 J-523241 NCGC00094476-03 S(+)-N,N-Diethyl-N'([8alpha]-6-methylergolin-8-yl)urea TDHL Terguride [INN] 1,1-diethyl-3-(6-methyl-8alpha-ergolinyl)urea Urea, N,N-diethyl-N'-((8-alpha)-6-methylergolin-8-yl)- 6-Methyl-8\|A-(diethylcarbamoylamino)ergoline API0004355 CHEMBL73151 EINECS 253-624-2 MLS000069833 Prestwick0_000945 S(+)-Terguride (5R, 8S, 10R) Tergurid Tox21_111283 1-((5R,8S,10R)-6-Methyl-8-ergolinyl)-3,3-diethylurea ZK 31224 9,10-alpha-Dihydrolisuride BRN 0766582 Dironyl HMS1570N12 N,N-Diethyl-N'-(D-6-methyl-10\|A-isoergolin-8-yl)urea Prestwick3_000927 SMR000058934 (+)-Terguride Transdihydrolisuride 37686-84-3 AC1L9FGP CHEBI:32193 DSSTox_RID_81146 JOAHPSVPXZTVEP-YXJHDRRASA-N NCGC00179409-02 s(+)-N,N-Diethyl-n([8alpha]-6-methylergolin-8-yl)urea Teluron Terguridum 1,1-Diethyl-3-(6-methylergolin-8alpha-yl)urea VUFB-6638 [ Show all ]
Inchi Key	JOAHPSVPXZTVEP-YXJHDRRASA-N
Inchi ID	InChI=1S/C20H28N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,11,14,16,18,21H,4-5,9-10,12H2,1-3H3,(H,22,25)/t14-,16+,18+/m0/s1
PubChem CID	443951
ChEMBL	CHEMBL73151
IUPHAR	56
BindingDB	50017519
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.76 nM	PMID12388666	BindingDB
Ki	0.794328 nM	PMID12388666	IUPHAR

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