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GPCR

NameFree fatty acid receptor 1
SpeciesRattus norvegicus (Rat)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProtQ8K3T4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795180
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2022250
Molecular formulaC25H25NO3
IUPAC name2-[2-[[3-(2,6-dimethylphenyl)phenyl]methoxy]-6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl]acetic acid
Molecular weight387.479
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.0
SynonymsBDBM50382531
Inchi KeyJLEQEHJFOVZXHU-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H25NO3/c1-16-5-3-6-17(2)25(16)20-8-4-7-18(13-20)15-29-23-12-10-21-19(14-24(27)28)9-11-22(21)26-23/h3-8,10,12-13,19H,9,11,14-15H2,1-2H3,(H,27,28)
PubChem CID57325678
ChEMBLCHEMBL2022250
IUPHARN/A
BindingDB50382531
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID22242551BindingDB,ChEMBL

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