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GLASS

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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL1256344
Molecular formula	C34H40N4O6
IUPAC name	ethyl 2-[3-[2-hydroxy-3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-2,5-dioxo-4,4-diphenylimidazolidin-1-yl]propanoate
Molecular weight	600.716
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.2
Synonyms	BDBM50417058
Inchi Key	AVGWWHGGUIZHBV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H40N4O6/c1-4-44-31(40)25(2)38-32(41)34(26-13-7-5-8-14-26,27-15-9-6-10-16-27)37(33(38)42)24-28(39)23-35-19-21-36(22-20-35)29-17-11-12-18-30(29)43-3/h5-18,25,28,39H,4,19-24H2,1-3H3
PubChem CID	11169638
ChEMBL	CHEMBL1256344
IUPHAR	N/A
BindingDB	50417058
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kd	70.79 nM	PMID20813529	BindingDB,ChEMBL

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