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GPCR

NameProstaglandin D2 receptor 2
SpeciesRattus norvegicus (Rat)
GenePtgdr2
SynonymPGD2 receptor
Gpr44
G protein-coupled receptor 44
DP2 receptor
CRTH2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length403
Amino acid sequenceMANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD
UniProtQ6XKD3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075112
IUPHAR339
DrugBankN/A

Ligand

NameCHEMBL1088284
Molecular formulaC25H17F3N2O2
IUPAC name2-[2-[bis(4-fluorophenyl)methyl]-4-(3-fluorophenyl)pyrimidin-5-yl]acetic acid
Molecular weight434.418
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP5.0
SynonymsBDBM50312906
SCHEMBL1226883
2-(2-(bis(4-fluorophenyl)methyl)-4-(3-fluorophenyl)pyrimidin-5-yl)acetic acid
Inchi KeyACFQRXVIUVXHIY-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H17F3N2O2/c26-19-8-4-15(5-9-19)23(16-6-10-20(27)11-7-16)25-29-14-18(13-22(31)32)24(30-25)17-2-1-3-21(28)12-17/h1-12,14,23H,13H2,(H,31,32)
PubChem CID16222207
ChEMBLCHEMBL1088284
IUPHARN/A
BindingDB50312906
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC507.5 nMPMID20137942BindingDB,ChEMBL

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