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GPCR

NamePyroglutamylated RF-amide peptide receptor
SpeciesHomo sapiens (Human)
GeneQRFPR
SynonymQRFP receptor
peptide p518 receptor
Orexigenic neuropeptide QRFP receptor
GPR103
G-protein coupled receptor 103
[ Show all ]
DiseaseN/A
Length431
Amino acid sequenceMQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProtQ96P65
Protein Data BankN/A
GPCR-HGmod modelQ96P65
3D structure modelThis predicted structure model is from GPCR-EXP Q96P65.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5852
IUPHAR333
DrugBankN/A

Ligand

NameCHEMBL1802416
Molecular formulaC70H103N21O15
IUPAC name(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-N-[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide
Molecular weight1478.73
Hydrogen bond acceptor20
Hydrogen bond donor22
XlogP-3.9
SynonymsBDBM50347826
Inchi KeyIZXBKKCBCNQZLO-GXTUYBNASA-N
Inchi IDInChI=1S/C70H103N21O15/c71-30-12-10-22-48(84-62(100)49(23-11-13-31-72)85-63(101)50(24-14-32-79-69(75)76)87-67(105)55(40-92)90-60(98)47(73)34-45-26-28-46(94)29-27-45)61(99)82-38-57(95)81-39-58(96)83-53(36-43-18-6-2-7-19-43)65(103)91-56(41-93)68(106)89-54(37-44-20-8-3-9-21-44)66(104)86-51(25-15-33-80-70(77)78)64(102)88-52(59(74)97)35-42-16-4-1-5-17-42/h1-9,16-21,26-29,47-56,92-94H,10-15,22-25,30-41,71-73H2,(H2,74,97)(H,81,95)(H,82,99)(H,83,96)(H,84,100)(H,85,101)(H,86,104)(H,87,105)(H,88,102)(H,89,106)(H,90,98)(H,91,103)(H4,75,76,79)(H4,77,78,80)/t47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m0/s1
PubChem CID53363097
ChEMBLCHEMBL1802416
IUPHARN/A
BindingDB50347826
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50138.0 nMPMID21623631BindingDB,ChEMBL

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