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Name | Neuropeptide Y receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | NPY1R |
Synonym | neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor [ Show all ] |
Disease | Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder [ Show all ] |
Length | 384 |
Amino acid sequence | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI |
UniProt | P25929 |
Protein Data Bank | 5zbh |
GPCR-HGmod model | P25929 |
3D structure model | This structure is from PDB ID 5zbh. |
BioLiP | BL0411971 |
Therapeutic Target Database | T89213 |
ChEMBL | CHEMBL4777 |
IUPHAR | 305 |
DrugBank | N/A |
Name | CHEMBL1771263 |
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Molecular formula | C24H31Cl2N5O2 |
IUPAC name | 1-N-[3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]-2-methyl-2-N-(oxan-4-yl)propane-1,2-diamine |
Molecular weight | 492.445 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 4.9 |
Synonyms | BDBM50342725 N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-2-methyl-N2-(tetrahydro-2H-pyran-4-yl)propane-1,2-diamine |
Inchi Key | ATUVDIADSMQSEJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H31Cl2N5O2/c1-14-10-20(27-13-24(3,4)29-16-6-8-33-9-7-16)31-23(28-14)21(15(2)30-31)22-18(25)11-17(32-5)12-19(22)26/h10-12,16,27,29H,6-9,13H2,1-5H3 |
PubChem CID | 54583519 |
ChEMBL | CHEMBL1771263 |
IUPHAR | N/A |
BindingDB | 50342725 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 141.0 nM | PMID21295475 | BindingDB,ChEMBL |
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