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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL1802364
Molecular formula	C43H59N11O7
IUPAC name	(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-methylpentanamide
Molecular weight	842.015
Hydrogen bond acceptor	9
Hydrogen bond donor	10
XlogP	1.2
Synonyms	BDBM50347836
Inchi Key	IWEGVYCMWNRHRJ-ZZTWKDBPSA-N
Inchi ID	InChI=1S/C43H59N11O7/c1-27(2)21-33(53-41(60)34(23-29-15-8-4-9-16-29)50-37(56)26-49-36(55)25-44)40(59)54-35(24-30-17-10-5-11-18-30)42(61)51-31(19-12-20-48-43(46)47)39(58)52-32(38(45)57)22-28-13-6-3-7-14-28/h3-11,13-18,27,31-35H,12,19-26,44H2,1-2H3,(H2,45,57)(H,49,55)(H,50,56)(H,51,61)(H,52,58)(H,53,60)(H,54,59)(H4,46,47,48)/t31-,32-,33-,34-,35-/m0/s1
PubChem CID	56676708
ChEMBL	CHEMBL1802364
IUPHAR	N/A
BindingDB	50347836
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1471.0 nM	PMID21623631	BindingDB,ChEMBL

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